Monthly Archives: December 2016

File in/out: How to import data files from Spike2 (and Matlab) into Python

Spike2 is a type of signal acquisition software commonly used in physiological studies (eg. electromyography, kinematics, cardiovascular research, sleep, etc). It is possible to perform signal analysis in Spike2 by using the drop-down menus, or by programming scripts to automate analysis. However, the programming language for Spike2 is difficult to read, which discourages many scientists from learning to program scripts

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Why we need confidence intervals

At Scientifically Sound, we have reviewed ongoing discussions on the benefits of confidence intervals (CIs) over p values for statistical analysis and reproducibility in research. In a short editorial, the statistician Doug Altman summarised why we need confidence intervals and showed how confidence intervals force investigators to consider sizes of effects. Here are the key points: Two different but complementary

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How are confidence intervals useful in understanding replication?

The growing awareness of the need for reproducibility in research is encouraging, but what does reproducible research actually look like in practice? Marty and I recently had an interesting discussion on what it means for a study’s findings to be independently replicated, and the metrics scientists use to interpret reproducibility. I tend to interpret level of reproducibility using confidence intervals

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Cultural factors contribute to poor reproducibility in the biomedical sciences

In two previous post (1, 2), I highlighted a symposium that was held to improve the reproducibility of biomedical research. The published report includes a discussion on cultural factors that have contributed to the high prevalence of irreproducible research. Culture and nature of science Whether or not the questionable research practices described in the previous post are the result of

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