Category Archives: News & research

Understanding interaction (subgroup) analysis in randomised studies

When we try to interpret findings from a study, we often like to understand whether an effect (of a treatment or test condition) might be different in subjects with different characteristics. If there was substantial variability among subjects, this may have masked a treatment effect in a select few. How can we understand effects in select groups of subjects that

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Why we need to report more than “Data were analysed by t-tests or ANOVA”

T-tests and analysis of variance (ANOVA) are common statistical tests in physiology and biomedical science. While the SAMPL guidelines for reporting statistical analyses and methods in published literature state authors should “describe statistical methods with enough detail to enable a knowledgeable reader with access to the original data to verify the reported results”, such recommendations are rarely implemented. Simply stating

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The challenge of open science for early career researchers

I assume that, if you are reading this post, you are familiar with research reproducibility and the issues that surround it. Nevertheless, you might not be familiar with the difficulties early career researchers face in this era of open science. A recent paper published in PLOS Biology by Allen & Meller entitled Open science challenges, benefits and tips in early

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Why Type I errors are worse than Type II errors

Most introductory statistics courses include a section explaining Type I (false positive) and Type II (false negative) errors in hypothesis testing. If you have been through such courses, you would have learned that the tolerance for Type I error is set by the significance level (alpha =0.05; the usual default) while Type II error is controlled by statistical power which

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